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CATCHR, HOPS and CORVET tethering complexes share a similar architecture.
- Source :
-
Nature structural & molecular biology [Nat Struct Mol Biol] 2016 Aug; Vol. 23 (8), pp. 761-3. Date of Electronic Publication: 2016 Jul 18. - Publication Year :
- 2016
-
Abstract
- We show here that the Saccharomyces cerevisiae GARP complex and the Cog1-4 subcomplex of the COG complex, both members of the complexes associated with tethering containing helical rods (CATCHR) family of multisubunit tethering complexes, share the same subunit organization. We also show that HOPS, a tethering complex acting in the endolysosomal pathway, shares a similar architecture, thus suggesting that multisubunit tethering complexes use related structural frameworks.
- Subjects :
- Adaptor Proteins, Vesicular Transport ultrastructure
Membrane Transport Proteins ultrastructure
Microscopy, Electron
Models, Molecular
Multiprotein Complexes ultrastructure
Protein Structure, Quaternary
Protein Subunits chemistry
Saccharomyces cerevisiae Proteins ultrastructure
Vesicular Transport Proteins ultrastructure
Saccharomyces cerevisiae ultrastructure
Subjects
Details
- Language :
- English
- ISSN :
- 1545-9985
- Volume :
- 23
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Nature structural & molecular biology
- Publication Type :
- Academic Journal
- Accession number :
- 27428774
- Full Text :
- https://doi.org/10.1038/nsmb.3264