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[Substances with antibacterial and antifungal activity. VI. Synthesis and microbiologic activity of new derivatives of 1,5-diarylpyrrole and 1,4-pyrrolphenylene].

Authors :
Porretta GC
Cerreto F
Fioravanti F
Biava M
Scalzo M
Fischetti M
Riccardi F
Source :
Farmaco (Societa chimica italiana : 1989) [Farmaco] 1989 Jan; Vol. 44 (1), pp. 51-63.
Publication Year :
1989

Abstract

New 1,5-diarylpyrrole and 1,4-pyrrolphenylene derivatives were prepared to study influence on the microbiological activity of an unsubstituted pyrrole nucleus or of a double identical molecular structure. Antimicrobial data in comparision with antifungal antibiotic pyrrolnitrin showed that all tested compounds exhibited very poor antifungal and antibacterial activity. Only some derivatives showed a selective activity against strains of Candida sp. and against strains of gram-positive or gram-negative bacteria.

Details

Language :
Italian
ISSN :
0014-827X
Volume :
44
Issue :
1
Database :
MEDLINE
Journal :
Farmaco (Societa chimica italiana : 1989)
Publication Type :
Academic Journal
Accession number :
2742721