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[Substances with antibacterial and antifungal activity. VI. Synthesis and microbiologic activity of new derivatives of 1,5-diarylpyrrole and 1,4-pyrrolphenylene].
- Source :
-
Farmaco (Societa chimica italiana : 1989) [Farmaco] 1989 Jan; Vol. 44 (1), pp. 51-63. - Publication Year :
- 1989
-
Abstract
- New 1,5-diarylpyrrole and 1,4-pyrrolphenylene derivatives were prepared to study influence on the microbiological activity of an unsubstituted pyrrole nucleus or of a double identical molecular structure. Antimicrobial data in comparision with antifungal antibiotic pyrrolnitrin showed that all tested compounds exhibited very poor antifungal and antibacterial activity. Only some derivatives showed a selective activity against strains of Candida sp. and against strains of gram-positive or gram-negative bacteria.
- Subjects :
- Anti-Bacterial Agents
Bacteria drug effects
Benzene Derivatives pharmacology
Fungi drug effects
Microbial Sensitivity Tests
Pyrroles pharmacology
Anti-Infective Agents chemical synthesis
Antifungal Agents chemical synthesis
Benzene Derivatives chemical synthesis
Pyrroles chemical synthesis
Subjects
Details
- Language :
- Italian
- ISSN :
- 0014-827X
- Volume :
- 44
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Farmaco (Societa chimica italiana : 1989)
- Publication Type :
- Academic Journal
- Accession number :
- 2742721