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The Yiqi and Yangyin Formula ameliorates injury to the hematopoietic system induced by total body irradiation.
- Source :
-
Journal of radiation research [J Radiat Res] 2017 Jan; Vol. 58 (1), pp. 1-7. Date of Electronic Publication: 2016 Jul 15. - Publication Year :
- 2017
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Abstract
- In this study, we examined whether the Yiqi and Yangyin Formula (YYF), used in traditional Chinese medicine, could ameliorate damage to the hematopoietic system induced by total body irradiation (TBI). Treatment with 15 g/kg of YYF increased the survival rate of Institute of Cancer Research (ICR) mice exposed to 7.5 Gy TBI. Furthermore, YYF treatment increased the white blood cell (WBC), red blood cell (RBC), hemoglobin (HGB) and hematocrit (HCT) counts in ICR mice exposed to 2 Gy or 4 Gy TBI. Treatment with YYF also increased the number of bone marrow cells, hematopoietic progenitor cells (HPCs), hematopoietic stem cells (HSCs) and the colony-forming ability of granulocyte-macrophage cells. YYF alleviated TBI-induced suppression of the differentiation ability of HPCs and HSCs and decreased the reactive oxygen species (ROS) levels in bone marrow mononuclear cells (BMMNCs), HPCs and HSCs from mice exposed to 2 Gy or 4 Gy TBI. Overall, our data suggest that YYF can ameliorate myelosuppression by reducing the intracellular ROS levels in hematopoietic cells after TBI at doses of 2 Gy and 4 Gy.<br /> (© The Author 2016. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology.)
- Subjects :
- Animals
Bone Marrow Cells drug effects
Bone Marrow Cells radiation effects
Cell Count
Cell Self Renewal drug effects
Cell Self Renewal radiation effects
Colony-Forming Units Assay
Hematopoietic Stem Cells radiation effects
Mice, Inbred ICR
Reactive Oxygen Species metabolism
Survival Analysis
Drugs, Chinese Herbal pharmacology
Hematopoietic Stem Cells drug effects
Hematopoietic Stem Cells pathology
Whole-Body Irradiation
Subjects
Details
- Language :
- English
- ISSN :
- 1349-9157
- Volume :
- 58
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of radiation research
- Publication Type :
- Academic Journal
- Accession number :
- 27422936
- Full Text :
- https://doi.org/10.1093/jrr/rrw056