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Glutamate: Tastant and Neuromodulator in Taste Buds.

Authors :
Vandenbeuch A
Kinnamon SC
Source :
Advances in nutrition (Bethesda, Md.) [Adv Nutr] 2016 Jul 15; Vol. 7 (4), pp. 823S-7S. Date of Electronic Publication: 2016 Jul 15 (Print Publication: 2016).
Publication Year :
2016

Abstract

In taste buds, glutamate plays a double role as a gustatory stimulus and neuromodulator. The detection of glutamate as a tastant involves several G protein-coupled receptors, including the heterodimer taste receptor type 1, member 1 and 3 as well as metabotropic glutamate receptors (mGluR1 and mGluR4). Both receptor types participate in the detection of glutamate as shown with knockout animals and selective antagonists. At the basal part of taste buds, ionotropic glutamate receptors [N-methyl-d-aspartate (NMDA) and non-NMDA] are expressed and participate in the modulation of the taste signal before its transmission to the brain. Evidence suggests that glutamate has an efferent function on taste cells and modulates the release of other neurotransmitters such as serotonin and ATP. This short article reviews the recent developments in the field with regard to glutamate receptors involved in both functions as well as the influence of glutamate on the taste signal.<br /> (© 2016 American Society for Nutrition.)

Details

Language :
English
ISSN :
2156-5376
Volume :
7
Issue :
4
Database :
MEDLINE
Journal :
Advances in nutrition (Bethesda, Md.)
Publication Type :
Academic Journal
Accession number :
27422519
Full Text :
https://doi.org/10.3945/an.115.011304