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The Plant-Derived Naphthoquinone Droserone Inhibits In Vitro Measles Virus Infection.

The Plant-Derived Naphthoquinone Droserone Inhibits In Vitro Measles Virus Infection.

Authors :
Lieberherr C
Zhang G
Grafen A
Singethan K
Kendl S
Vogt V
Maier J
Bringmann G
Schneider-Schaulies J
Source :
Planta medica [Planta Med] 2017 Feb; Vol. 83 (3-04), pp. 232-238. Date of Electronic Publication: 2016 Jul 15.
Publication Year :
2017

Abstract

The naphthoquinone droserone ( 1 ) is a natural product occurring in dicotyledonous plants. We have now observed that the addition of 1 during infection of tissue culture cells with measles virus considerably reduced the infection. Interestingly, the infection was inhibited only when droserone ( 1 ) was added during virus entry, but not when added to the cells prior to virus uptake or after virus uptake. These findings suggest that 1 interacts with viral particles to reduce infectivity. The formation of progeny measles virus particles was inhibited to 50 % by droserone ( 1 ) at a concentration (IC <subscript>50</subscript> ) of approximately 2 µM with a half-maximal cytotoxicity (CC <subscript>50</subscript> ) of about 60 µM for Vero cells. Other tested naphthoquinone derivatives, among them the likewise natural plumbagin ( 2 ), but also synthetic analogs, were either more cytotoxic or not as effective as 1 . Thus, our data do not support the development of naphthoquinone derivatives into antiviral compounds, but suggest that they may be interesting research tools to study measles virus entry into cells.<br /> (Georg Thieme Verlag KG Stuttgart · New York.)

Details

Language :
English
ISSN :
1439-0221
Volume :
83
Issue :
3-04
Database :
MEDLINE
Journal :
Planta medica
Publication Type :
Academic Journal
Accession number :
27420351
Full Text :
https://doi.org/10.1055/s-0042-111825