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Effect of Different Concentrations of Chlorhexidine in Glass-ionomer Cements on In Vivo Biocompatibility.
- Source :
-
The journal of adhesive dentistry [J Adhes Dent] 2016; Vol. 18 (4), pp. 325-30. - Publication Year :
- 2016
-
Abstract
- Purpose: To examine whether a difference exists between the in vivo biocompatibility of glass-ionomer cements (GICs) containing chlorhexidine (CHX) in different concentrations.<br />Materials and Methods: Eighty-four male Wistar rats were distributed into 7 groups (n = 12) and received subcutaneous implants of small tubes containing different materials, as follows: Ketac control (K), Ketac-CHX 10% (K10), Ketac-CHX 18% (K18), Resilience control (R), Resilience-CHX 10% (R10), Resilience-CHX 18% (R18), Control (polyethylene). The animals were then sacrificed on post-insertion days 7, 15 and 30, and tissues were examined under an optical microscope for inflammatory infiltrate, edema, necrosis, granulation tissue, multinucleated giant cells, and collagen fibers. The results were statistically analyzed using Kruskal-Wallis and Dunn's tests (p < 0.05).<br />Results: Groups K18 and R18 showed larger areas of intense inflammatory infiltrate, with significant differences between group C and groups K18 and R18 (p = 0.007) at 7 days, and between groups C and K18 (p = 0.017) at 15 days. In terms of tissue repair, groups K18 and R18 demonstrated a lower quantity of collagen fibers with significant differences from group C (p = 0.019) at 7 days, and between group K18 and group C (p = 0.021) at 15 days.<br />Conclusion: The 18% concentration of CHX was shown to have a toxic effect. The 10% concentration of CHX was shown to be suitable for tissue contact. The addition of CHX to the glass-ionomer cements is a highly promising method for obtaining of an antibacterial GIC for use in clinical practice.
- Subjects :
- Acrylic Resins chemistry
Acrylic Resins toxicity
Animals
Anti-Infective Agents, Local chemistry
Anti-Infective Agents, Local toxicity
Biocompatible Materials chemistry
Carbonic Acid chemistry
Carbonic Acid toxicity
Chlorhexidine chemistry
Chlorhexidine toxicity
Collagen drug effects
Dental Materials chemistry
Dental Materials toxicity
Edema chemically induced
Fibroblasts drug effects
Giant Cells drug effects
Glass Ionomer Cements chemistry
Granulation Tissue drug effects
Magnesium Oxide chemistry
Magnesium Oxide toxicity
Male
Materials Testing
Necrosis
Polycarboxylate Cement chemistry
Polycarboxylate Cement toxicity
Polyethylene chemistry
Random Allocation
Rats
Subcutaneous Tissue drug effects
Zinc Oxide chemistry
Zinc Oxide toxicity
Anti-Infective Agents, Local administration & dosage
Biocompatible Materials toxicity
Chlorhexidine administration & dosage
Glass Ionomer Cements toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1461-5185
- Volume :
- 18
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The journal of adhesive dentistry
- Publication Type :
- Academic Journal
- Accession number :
- 27419241
- Full Text :
- https://doi.org/10.3290/j.jad.a36512