A model to predict anti-tuberculosis activity: value proposition for marine microorganisms.

Authors :: Liu M
Grkovic T
Zhang L
Liu X
Quinn RJ
Source :: The Journal of antibiotics [J Antibiot (Tokyo)] 2016 Aug; Vol. 69 (8), pp. 594-9. Date of Electronic Publication: 2016 Jul 13.
Publication Year :: 2016
Abstract: The development of new antibiotics effective against all strains of tuberculosis (TB) is needed. To evaluate the potential of marine microbe-derived natural products as anti-TB leads, we analyzed and compared the physico-chemical properties of 39 current TB drugs and candidates against 60 confirmed mycobacteria-active natural products. We showed that anti-TB natural products sourced from marine microbes have a large overlap with TB drug-like space. A model to predict potential anti-TB drugs is proposed.

Subjects :: Antitubercular Agents chemistry
Antitubercular Agents isolation & purification
Aquatic Organisms microbiology
Biological Products chemistry
Biological Products isolation & purification
Humans
Models, Theoretical
Mycobacterium tuberculosis drug effects
Tuberculosis drug therapy
Tuberculosis microbiology
Antitubercular Agents pharmacology
Biological Products pharmacology
Drug Design

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