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Analysis of 25 C NBOMe in Seized Blotters by HPTLC and GC-MS.
- Source :
-
Journal of chromatographic science [J Chromatogr Sci] 2016 Aug; Vol. 54 (7), pp. 1153-8. - Publication Year :
- 2016
-
Abstract
- Use of unauthorized synthetic drugs is a serious, forensic, regulatory and public health issue. In this scenario, consumption of drug-impregnated blotters is very frequent. For decades, blotters have been generally impregnated with the potent hallucinogen known as lysergic acid diethylamide (LSD); however, since 2013 blotter stamps with N-2 methoxybenzyl-substituted phenylethylamine hallucinogen designated as "NBOMes" have been seized in Chile. To address this issue with readily accessible laboratory equipment, we have developed and validated a new HPTLC method for the identification and quantitation of 25-C-NBOMe in seized blotters and its confirmation by GC-MS. The proposed method was validated according to SWGTOX recommendations and is suitable for routine analysis of seized blotters containing 25-C-NBOMe. With the validated method, we analyzed 15 real samples, in all cases finding 25-C-NBOMe in a wide dosage range (701.0-1943.5 µg per blotter). In this situation, we can assume that NBOMes are replacing LSD as the main hallucinogenic drug consumed in blotters in Chile.<br /> (© The Author 2016. Published by Oxford University Press.)
- Subjects :
- Administration, Sublingual
Adsorption
Chile
Chromatography, Thin Layer methods
Humans
Paper
Reproducibility of Results
Sensitivity and Specificity
Chromatography, Thin Layer standards
Gas Chromatography-Mass Spectrometry standards
Hallucinogens isolation & purification
Illicit Drugs isolation & purification
Phenethylamines isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1945-239X
- Volume :
- 54
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of chromatographic science
- Publication Type :
- Academic Journal
- Accession number :
- 27406128
- Full Text :
- https://doi.org/10.1093/chromsci/bmw095