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Pleiotropic Hes-1 Concomitant with its Differential Activation Mediates Neural Stem Cell Maintenance and Radial Glial Propensity in Developing Neocortex.
- Source :
-
Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2017 Aug 01; Vol. 27 (8), pp. 3943-3961. - Publication Year :
- 2017
-
Abstract
- Notch signaling pathway and its downstream effector Hes-1 are well known for their role in cortical neurogenesis. Despite the canonical activation of Hes-1 in developing neocortex, recent advances have laid considerable emphasis on Notch/CBF1-independent Hes-1 (NIHes-1) expression with poor understanding of its existence and functional significance. Here, using reporter systems and in utero electroporation, we could qualitatively unravel the existence of NIHes-1 expressing neural stem cells from the cohort of dependent progenitors throughout the mouse neocortical development. Though Hes-1 expression is maintained in neural progenitor territory at all times, a simple shift from Notch-independent to -dependent state makes it pleiotropic as the former maintains the neural stem cells in a non-dividing/slow-dividing state, whereas the latter is very much required for maintenance and proliferation of radial glial cells. Therefore, our results provide an additional complexity in neural progenitor heterogeneity regarding differential Hes-1 expression in the germinal zone during neo-cortical development.<br /> (© The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- Animals
Cell Proliferation physiology
Cells, Cultured
Ependymoglial Cells cytology
Gene Expression Regulation, Developmental physiology
HEK293 Cells
Humans
Mice, Inbred BALB C
Mice, Transgenic
Neocortex cytology
Neural Stem Cells cytology
Neurons cytology
Neurons metabolism
Receptors, Notch metabolism
Signal Transduction
Stem Cell Niche physiology
Ependymoglial Cells metabolism
Neocortex growth & development
Neocortex metabolism
Neural Stem Cells metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2199
- Volume :
- 27
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Cerebral cortex (New York, N.Y. : 1991)
- Publication Type :
- Academic Journal
- Accession number :
- 27405330
- Full Text :
- https://doi.org/10.1093/cercor/bhw207