Synthesis and Anti-Proliferative Activity of Sulfanyltriazolylnaphthalenols and Sulfanyltriazolylnaphthalene-1,4-diones.

Authors :: Chaaban I
El Khawass el SM
Abd El Razik HA
El Salamouni NS
Redondo-Horcajo M
Barasoain I
Díaz JF
Yli-Kauhaluoma J
Moreira VM
Source :: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2016 Sep; Vol. 349 (9), pp. 749-61. Date of Electronic Publication: 2016 Jul 12.
Publication Year :: 2016
Abstract: A series of new sulfanyltriazolylnaphthalenols (10a-f and 13a-f) and sulfanyltriazolylnaphthalene-1,4-diones (14a-f) were synthesized and evaluated against a panel of cancer cell lines. Among the tested compounds, 10b and 10d showed the best anti-proliferative activity with GI50 values ranging from 2.72 to 10 and 3.13 to 13.1 µM, respectively, in several of the tumor cell lines tested. Compound 10d is highly selective toward leukemia cell lines and can be regarded as a good model for the development of new anti-leukemic agents.<br /> (© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Antineoplastic Agents chemistry
Cell Line, Tumor
Drug Screening Assays, Antitumor
Humans
Naphthalenes chemistry
Structure-Activity Relationship
Antineoplastic Agents chemical synthesis
Antineoplastic Agents pharmacology
Cell Proliferation drug effects
Naphthalenes chemical synthesis
Naphthalenes pharmacology

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