Oct4B, CD90, and CD73 are upregulated in bladder tissue following electro-resection of the bladder.

Authors :: Takeuchi T
Tonooka A
Okuno Y
Hattori-Kato M
Mikami K
Source :: Journal of stem cells & regenerative medicine [J Stem Cells Regen Med] 2016 May 30; Vol. 12 (1), pp. 10-5. Date of Electronic Publication: 2016 May 30 (Print Publication: 2016).
Publication Year :: 2016
Abstract: Aim: We tested the hypothesis that stimulation by electro-resection of bladder tissue induces stem cells in the tissue repair process.<br />Materials & Methods: After primary transurethral resection of a bladder tumor and surrounding tissue (TUR-Bt), second TUR-Bt was performed. Tissues excised by second TUR-Bt were immunohistochemically stained for Oct4, a marker of pluripotency, and for CD90 and CD73, markers of mesenchymal stromal cells, when no bladder tumor cells remained.<br />Results and Conclusions: Oct4B protein was sporadically stained in the cytoplasm of interstitial cells in four out of eight cases. CD90 and CD73 are upregulated in interstitial and vascular endothelial cells without CD45 expression. Mesenchymal stromal cells, but not pluripotent stem cells, may be mainly involved in bladder tissue repair.

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