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Diversity and function of group 1 innate lymphoid cells.
- Source :
-
Immunology letters [Immunol Lett] 2016 Nov; Vol. 179, pp. 19-24. Date of Electronic Publication: 2016 Jul 06. - Publication Year :
- 2016
-
Abstract
- Innate lymphoid cells (ILCs) are a heterogeneous population of cells with diverse roles in immune responses. Three major groups of ILCs have been defined on the basis of similarity in their production of signature cytokines, developmental requirements, and phenotypic markers. Group 1 ILCs produce IFN-γ, express the T-box transcription factors (TF) T-bet and/or Eomesodermin (Eomes), group 2 ILCs secrete IL-5 and IL-13 and express the TF GATA-3, while group 3 ILCs produce IL-22 and IL-17 and express the TF RORgt. In this review, we will briefly overview each group in terms of phenotype, function and development and then focus more extensively on group 1 ILCs, expanding on their emerging diversity, their disparate functions and the differences between NK cells and ILC1.<br /> (Copyright © 2016. Published by Elsevier B.V.)
- Subjects :
- Animals
Biomarkers
Cell Differentiation genetics
Cell Differentiation immunology
Cell Plasticity genetics
Cytokines metabolism
Disease Susceptibility
Gene Expression Regulation, Developmental
Humans
Interferon-gamma biosynthesis
Killer Cells, Natural cytology
Killer Cells, Natural immunology
Killer Cells, Natural metabolism
Lymphocyte Subsets cytology
Organ Specificity
Phenotype
Transcription Factors genetics
Transcription Factors metabolism
Cell Plasticity immunology
Immunity, Innate
Lymphocyte Subsets immunology
Lymphocyte Subsets metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0542
- Volume :
- 179
- Database :
- MEDLINE
- Journal :
- Immunology letters
- Publication Type :
- Academic Journal
- Accession number :
- 27394699
- Full Text :
- https://doi.org/10.1016/j.imlet.2016.07.005