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Effects of pre- and post-natal lipid-based nutrient supplements on infant development in a randomized trial in Ghana.
- Source :
-
Early human development [Early Hum Dev] 2016 Aug; Vol. 99, pp. 43-51. Date of Electronic Publication: 2016 Jul 06. - Publication Year :
- 2016
-
Abstract
- Background: Maternal and infant undernutrition is negatively associated with infant development.<br />Aims: We tested the hypothesis that provision of small-quantity lipid-based nutrient supplements (SQ-LNS) to pregnant women and infants positively affects infant development.<br />Study Design: In a partially double-blind randomized controlled trial, we compared the following daily maternal supplements during pregnancy and until 6months post-partum: iron/folic acid capsule (IFA), capsule containing 18 micronutrients (MMN), or 20g SQ-LNS. Children in the SQ-LNS group also received SQ-LNS from age 6 to 18months. The study is registered as NCT00970866.<br />Subjects: 1320 pregnant women in Ghana enrolled in the trial; 1173 of their children participated in developmental assessment.<br />Outcome Measures: We monitored the acquisition of 10 developmental milestones monthly by parental report, observed the attainment of 6 motor milestones at 6, 12, and 18months, and conducted detailed assessment of motor, language, socio-emotional, and executive function at 18months.<br />Results: By researcher observation, a greater percentage of children in the SQ-LNS group (53%) was able to walk alone at 12months than in the IFA group (43%; RR=1.23, 95% CI=1.02-1.49; p=0.025). We found no significant differences between groups in milestone acquisition by parent report or in any scores at 18months. The difference in mean z-scores between groups ranged from 0.03-0.13 for motor (p=0.84), 0.01-0.08 for language (p=0.46), 0.01-0.02 for socio-emotional (p=0.75), and 0.00-0.02 for executive function (p=0.95).<br />Conclusion: While provision of maternal and child SQ-LNS in Ghana may affect walking at 12months, it did not affect infant development at 18months.<br /> (Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Adult
Fatty Acids administration & dosage
Female
Ghana
Humans
Infant Nutritional Physiological Phenomena
Infant, Newborn
Male
Malnutrition prevention & control
Maternal Nutritional Physiological Phenomena
Micronutrients administration & dosage
Pregnancy
Child Development
Dietary Supplements
Fatty Acids therapeutic use
Malnutrition therapy
Micronutrients therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1872-6232
- Volume :
- 99
- Database :
- MEDLINE
- Journal :
- Early human development
- Publication Type :
- Academic Journal
- Accession number :
- 27391572
- Full Text :
- https://doi.org/10.1016/j.earlhumdev.2016.05.011