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Reproducibility of coronary atherosclerotic plaque characteristics in populations with low, intermediate, and high prevalence of coronary artery disease by multidetector computer tomography: a guide to reliable visual coronary plaque assessments.
- Source :
-
The international journal of cardiovascular imaging [Int J Cardiovasc Imaging] 2016 Oct; Vol. 32 (10), pp. 1555-66. Date of Electronic Publication: 2016 Jul 04. - Publication Year :
- 2016
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Abstract
- To evaluate the interobserver agreement of visual coronary plaque characteristics by 320-slice multidetector computed tomography (MDCT) in three populations with low, intermediate and high CAD prevalence and to identify determinants for the reproducible assessment of these plaque characteristics. 150 patients, 50 asymptomatic subjects from the general population (low CAD prevalence), 50 symptomatic non-acute coronary syndrome (non-ACS) patients (intermediate CAD prevalence), and 50 ACS patients (high CAD prevalence), matched according to age and gender, were retrospectively enrolled. All coronary segments were evaluated for overall image quality, evaluability, presence of CAD, coronary stenosis, plaque composition, plaque focality, and spotty calcification by four readers. Interobserver agreement was assessed using Fleiss' Kappa (κ) and intra-class correlation (ICC). Widely used clinical parameters (overall scan quality, presence of CAD, and determination of coronary stenosis) showed good agreement among the four readers, (ICC = 0.66, κ = 0.73, ICC = 0.74, respectively). When accounting for heart rate, body mass index, plaque location, and coronary stenosis above/below 50 %, interobserver agreement for plaque composition, presence of CAD, and coronary stenosis improved to either good or excellent, (κ = 0.61, κ = 0.81, ICC = 0.78, respectively). Spotty calcification was the least reproducible parameter investigated (κ = 0.33). Across subpopulations, reproducibility of coronary plaque characteristics generally decreased with increasing CAD prevalence except for plaque composition, (limits of agreement: ±2.03, ±1.96, ±1.79 for low, intermediate and high CAD prevalence, respectively). 320-slice MDCT can be used to assess coronary plaque characteristics, except for spotty calcification. Reproducibility estimates are influenced by heart rate, body size, plaque location, and degree of luminal stenosis.
- Subjects :
- Aged
Denmark epidemiology
Female
Humans
Male
Middle Aged
Observer Variation
Plaque, Atherosclerotic
Predictive Value of Tests
Prevalence
Reproducibility of Results
Retrospective Studies
Vascular Calcification diagnostic imaging
Vascular Calcification epidemiology
Computed Tomography Angiography
Coronary Angiography methods
Coronary Artery Disease diagnostic imaging
Coronary Artery Disease epidemiology
Coronary Stenosis diagnostic imaging
Coronary Stenosis epidemiology
Coronary Vessels diagnostic imaging
Multidetector Computed Tomography
Subjects
Details
- Language :
- English
- ISSN :
- 1875-8312
- Volume :
- 32
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The international journal of cardiovascular imaging
- Publication Type :
- Academic Journal
- Accession number :
- 27378095
- Full Text :
- https://doi.org/10.1007/s10554-016-0932-y