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Self-reported depression in psoriasis is associated with subclinical vascular diseases.
- Source :
-
Atherosclerosis [Atherosclerosis] 2016 Aug; Vol. 251, pp. 219-225. Date of Electronic Publication: 2016 May 27. - Publication Year :
- 2016
-
Abstract
- Background and Aims: Psoriasis is a chronic inflammatory disorder associated with vascular inflammation, measured by 18-fluorodeoxyglucose positron emission tomography/computed tomography (18-FDG PET/CT), and an increased risk of myocardial infarction. Patients with psoriasis are also more likely to suffer from comorbid depression. Whether depression accelerates the development of subclinical atherosclerosis in psoriasis is unknown.<br />Methods: Patients were selected from within a larger psoriasis cohort. Those who reported a history of depression (N = 36) on survey were matched by age and gender to patients who reported no history of psychiatric illness (N = 36). Target-to-background ratio from FDG PET/CT was used to assess aortic vascular inflammation and coronary CT angiography scans were analyzed to determine coronary plaque burden. Multivariable linear regression was performed to understand the effect of self-reported depression on vascular inflammation and coronary plaque burden after adjustment for Framingham risk (standardized β reported).<br />Results: In unadjusted analyses, vascular inflammation and coronary plaque burden were significantly increased in patients with self-reported depression as compared to patients with psoriasis alone. After adjustment for Framingham Risk Score, vascular inflammation (β = 0.26, p = 0.02), total plaque burden (β = 0.17, p = 0.03), and non-calcified burden (β = 0.17, p = 0.03) were associated with self-reported depression.<br />Conclusions: Self-reported depression in psoriasis is associated with increased vascular inflammation and coronary plaque burden. Depression may play an important role in promoting subclinical atherosclerosis beyond traditional cardiovascular risk factors.<br />Competing Interests: The authors confirm that there are no other potential conflicts of interest.<br /> (Published by Elsevier Ireland Ltd.)
- Subjects :
- Cardiovascular Diseases complications
Cohort Studies
Comorbidity
Computed Tomography Angiography
Coronary Vessels pathology
Depression complications
Female
Glomerular Filtration Rate
Humans
Inflammation
Male
Middle Aged
Multivariate Analysis
Positron Emission Tomography Computed Tomography
Psoriasis complications
Risk Factors
Severity of Illness Index
Tomography, X-Ray Computed
Vascular Diseases complications
Vascular Diseases diagnosis
Depression diagnosis
Psoriasis psychology
Self Report
Vascular Diseases psychology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1484
- Volume :
- 251
- Database :
- MEDLINE
- Journal :
- Atherosclerosis
- Publication Type :
- Academic Journal
- Accession number :
- 27376696
- Full Text :
- https://doi.org/10.1016/j.atherosclerosis.2016.05.043