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Deep brain stimulation of the internal globus pallidus for disabling haloperidol-induced tardive dystonia. Report of two cases.
- Source :
-
Neurologia i neurochirurgia polska [Neurol Neurochir Pol] 2016 Jul-Aug; Vol. 50 (4), pp. 258-61. Date of Electronic Publication: 2016 Apr 26. - Publication Year :
- 2016
-
Abstract
- Aim: Tardive dystonia (TD) represents a side effect of prolonged intake of neuroleptic drugs. TD can be a disabling movement disorder persisting despite available medical treatment. Deep brain stimulation (DBS) has been reported successful in this condition although the number of treated patients with TD is still limited to small clinical studies or case reports. In this study, we present 2 additional cases of patients after bilateral globus pallidus internus (GPi) stimulation.<br />Methods: The formal assessment included the Burke-Fahn-Dystonia Rating Scale (BFMDRS). The preoperative and postoperative functional and motor parts of this scale were compared in each patient. The postoperative assessments were done every 6 months.<br />Results: Both patients underwent successful bilateral GPi DBS for TD. The postoperative motor score improved by 78% at 24 months in patient 1 and 69% at 12 months in patient 2. There were no surgical or hardware-related complications over follow-up period.<br />Conclusion: Our experience indicates that bilateral GPi DBS can be an effective treatment for disabling TD. The response of TD to bilateral GPi DBS is very rapid and occurs within days after the procedure.<br /> (Copyright © 2016 Polish Neurological Society. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.)
- Subjects :
- Adult
Antipsychotic Agents therapeutic use
Bipolar Disorder drug therapy
Depressive Disorder drug therapy
Haloperidol therapeutic use
Humans
Male
Middle Aged
Tardive Dyskinesia physiopathology
Treatment Outcome
Antipsychotic Agents adverse effects
Deep Brain Stimulation methods
Globus Pallidus physiopathology
Haloperidol adverse effects
Tardive Dyskinesia therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0028-3843
- Volume :
- 50
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Neurologia i neurochirurgia polska
- Publication Type :
- Academic Journal
- Accession number :
- 27375139
- Full Text :
- https://doi.org/10.1016/j.pjnns.2016.04.006