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Reactivation of Human Herpes Virus-6 in the Renal Tissue of a Patient with Drug-induced Hypersensitivity Syndrome/Drug Rash with Eosinophilia and Systemic Symptoms (DIHS/DRESS).
- Source :
-
Internal medicine (Tokyo, Japan) [Intern Med] 2016; Vol. 55 (13), pp. 1769-74. Date of Electronic Publication: 2016 Jul 01. - Publication Year :
- 2016
-
Abstract
- A 74-year-old man who had been administered trimethoprim-sulfamethoxazole for three weeks suffered from drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS). In the early stage of the clinical course, he developed renal dysfunction. A renal biopsy showed granulomatous tubulointerstitial nephritis accompanying the proliferation of human herpes virus (HHV)-6 in tubular epithelial cells. With corticosteroid therapy, the systemic rash and renal function gradually improved. The present patient is the second case of DIHS/DRESS demonstrating a possible reactivation of HHV-6 in the renal tissue. The clinical role of viral reactivation in DIHS/DRESS must be further elucidated.
- Subjects :
- Adrenal Cortex Hormones therapeutic use
Aged
Anti-Bacterial Agents adverse effects
Drug Hypersensitivity Syndrome drug therapy
Drug Hypersensitivity Syndrome etiology
Humans
Male
Trimethoprim, Sulfamethoxazole Drug Combination adverse effects
Drug Hypersensitivity Syndrome complications
Eosinophilia complications
Herpesvirus 6, Human physiology
Renal Insufficiency complications
Renal Insufficiency virology
Subjects
Details
- Language :
- English
- ISSN :
- 1349-7235
- Volume :
- 55
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Internal medicine (Tokyo, Japan)
- Publication Type :
- Academic Journal
- Accession number :
- 27374681
- Full Text :
- https://doi.org/10.2169/internalmedicine.55.6287