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[Advance research on the pathogenesis of middle ear cholesteatoma].
- Source :
-
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery [Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi] 2016 Feb; Vol. 30 (4), pp. 338-41. - Publication Year :
- 2016
-
Abstract
- Cholesteatoma is a non-neoplastic, keratinizing lesion, characterized by the proliferation of epithelium with aberrant micro-architecture into the middle ear or mastoid cavity. The exact pathogenic molecular mechanisms behind the formation and propagation of cholesteatoma remain unclear. Without timely detection and intervention, cholesteatomas can become dangerous and result in numerous intracranial and extracranial complications. In this review, the current researches about inflammatory mediators, enzymatic activity, growth factors, oxidative stress,infection and genetics in acquired cholesteatoma pathogenesis are discussed.
- Subjects :
- Ear, Middle pathology
Humans
Mastoid pathology
Cholesteatoma, Middle Ear pathology
Subjects
Details
- Language :
- Chinese
- ISSN :
- 2096-7993
- Volume :
- 30
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
- Publication Type :
- Academic Journal
- Accession number :
- 27373050