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Statin use and uterine fibroid risk in hyperlipidemia patients: a nested case-control study.
- Source :
-
American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2016 Dec; Vol. 215 (6), pp. 750.e1-750.e8. Date of Electronic Publication: 2016 Jun 28. - Publication Year :
- 2016
-
Abstract
- Background: Statins are 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors primarily used for treatment of hyperlipidemia. Recently, they have been shown to inhibit proliferation of uterine fibroid cells and inhibit tumor growth in fibroid animal models.<br />Objective: We sought to examine the association between statin use and the risk of uterine fibroids and fibroid-related symptoms in a nationally representative sample of commercially insured women diagnosed with hyperlipidemia.<br />Study Design: We performed a nested case-control study of >190,000 women enrolled in one of the nation's largest commercial health insurance programs. From a cohort of women aged 18-65 years diagnosed with hyperlipidemia from January 2004 through March 2011, we identified 47,713 cases (women diagnosed with uterine fibroids) and 143,139 controls (women without uterine fibroids) matched at a 1:3 ratio on event/index date (month and year) and age (±1 year). We used conditional and unconditional logistic regression to calculate odds ratios and 95% confidence intervals for the risk of uterine fibroids and fibroid-related symptoms associated with prior use of statins.<br />Results: Exposure to statins within 2 years before the event/index date was associated with a decreased risk of uterine fibroids (odds ratio, 0.85; 95% confidence interval, 0.83-0.87). In a separate subanalysis restricted to cases, statin users had a lower likelihood of having menorrhagia (odds ratio, 0.88; 95% confidence interval, 0.84-0.91), anemia (odds ratio, 0.84; 95% confidence interval, 0.79-0.88), or pelvic pain (odds ratio, 0.85; 95% confidence interval, 0.81-0.91) and of undergoing myomectomy (odds ratio, 0.76; 95% confidence interval, 0.66-0.87) compared to nonusers.<br />Conclusion: The use of statins was associated with a lower risk of uterine fibroids and fibroid-related symptoms. Further studies, including randomized controlled trials, may be warranted.<br /> (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Subjects :
- Adolescent
Adult
Aged
Anemia epidemiology
Case-Control Studies
Female
Humans
Logistic Models
Middle Aged
Odds Ratio
Protective Factors
United States epidemiology
Young Adult
Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use
Hyperlipidemias drug therapy
Hysterectomy statistics & numerical data
Leiomyoma epidemiology
Menorrhagia epidemiology
Pelvic Pain epidemiology
Uterine Myomectomy statistics & numerical data
Uterine Neoplasms epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6868
- Volume :
- 215
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- American journal of obstetrics and gynecology
- Publication Type :
- Academic Journal
- Accession number :
- 27371355
- Full Text :
- https://doi.org/10.1016/j.ajog.2016.06.036