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Metabolic Syndrome as a Risk Factor for Alzheimer's Disease: Is Aβ a Crucial Factor in Both Pathologies?
- Source :
-
Antioxidants & redox signaling [Antioxid Redox Signal] 2017 Apr 01; Vol. 26 (10), pp. 542-560. Date of Electronic Publication: 2016 Aug 16. - Publication Year :
- 2017
-
Abstract
- Significance: Recently, chronic degenerative diseases have become one of the main health problems worldwide. That is the case of Alzheimer's disease (AD) and metabolic syndrome (MetS), whose expression can be influenced by different risk factors. Recent Advances: In recent decades, it has been widely described that MetS increases the risk of cognitive impairment and dementia. MetS pathogenesis involves several vascular risk factors such as diabetes, dyslipidemia, hypertension, and insulin resistance (I/R).<br />Critical Issues: Reported evidence shows that vascular risk factors are associated with AD, particularly in the development of protein aggregation, inflammation, oxidative stress, neuronal dysfunction, and disturbances in signaling pathways, with insulin receptor signaling being a common alteration between MetS and AD.<br />Future Directions: Insulin signaling has been involved in tau phosphorylation and amyloid β (Aβ) metabolism. However, it has also been demonstrated that Aβ oligomers can bind to insulin receptors, triggering their internalization, decreasing neuron responsiveness to insulin, and promoting insulin I/R. Thus, it could be argued that Aβ could be a convergent factor in the development of both pathologies. Antioxid. Redox Signal. 26, 542-560.
- Subjects :
- Alzheimer Disease pathology
Animals
Brain metabolism
Brain pathology
Humans
Inflammation genetics
Inflammation immunology
Inflammation metabolism
Insulin Resistance
Lipid Metabolism
Neurons metabolism
Neurons pathology
Oxidative Stress
Protein Aggregation, Pathological
Proteolysis
Risk Factors
Signal Transduction
Alzheimer Disease etiology
Alzheimer Disease metabolism
Amyloid beta-Peptides metabolism
Metabolic Syndrome complications
Subjects
Details
- Language :
- English
- ISSN :
- 1557-7716
- Volume :
- 26
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Antioxidants & redox signaling
- Publication Type :
- Academic Journal
- Accession number :
- 27368351
- Full Text :
- https://doi.org/10.1089/ars.2016.6768