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Sorting Out Presenilins in Alzheimer's Disease.
- Source :
-
Cell [Cell] 2016 Jun 30; Vol. 166 (1), pp. 13-5. - Publication Year :
- 2016
-
Abstract
- Mutations in the presenilins that cause familial Alzheimer's disease alter the activity of these proteases to increase generation of an aggregation-prone isoform of the amyloid β-peptide (Aβ). How these mutations do so has been unclear. Sannerud et al. now show that regulation of subcellular localization plays a central role, advancing our understanding of the cell biology of Alzheimer's disease.<br /> (Copyright © 2016 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1097-4172
- Volume :
- 166
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cell
- Publication Type :
- Academic Journal
- Accession number :
- 27368096
- Full Text :
- https://doi.org/10.1016/j.cell.2016.06.034