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Impaired dynamic cerebrovascular response to hypercapnia predicts development of white matter hyperintensities.
- Source :
-
NeuroImage. Clinical [Neuroimage Clin] 2016 May 14; Vol. 11, pp. 796-801. Date of Electronic Publication: 2016 May 14 (Print Publication: 2016). - Publication Year :
- 2016
-
Abstract
- Purpose: To evaluate the relationship between both dynamic and steady-state measures of cerebrovascular reactivity (CVR) and the progression of age-related white matter disease.<br />Methods: Blood oxygen level-dependent (BOLD) MRI CVR scans were acquired from forty-five subjects (age range: 50-90 years, 25 males) with moderate to severe white matter disease, at baseline and one-year follow-up. To calculate the dynamic (τ) and steady-state (ssCVR) components of the BOLD signal response, the PETCO2 signal waveform was convolved with an exponential decay function. The τ corresponding to the best fit between the convolved PETCO2 and BOLD signal defined the speed of response, and the slope of the regression between the convolved PETCO2 and BOLD signal defined ssCVR. ssCVR and τ were compared between normal-appearing white matter (NAWM) that remains stable over time and NAWM that progresses to white matter hyperintensities (WMHs).<br />Results: In comparison to contralateral NAWM, NAWM that progressed to WMH had significantly lower ssCVR values by mean (SD) 46.5 (7.6)%, and higher τ values by 31.9 (9.6)% (both P < 0.01).<br />Conclusions: Vascular impairment in regions of NAWM that progresses to WMH consists not only of decreased magnitude of ssCVR, but also a pathological decrease in the speed of vascular response. These findings support the association between cerebrovascular dysregulation and the development of WMH.
- Subjects :
- Aged
Aged, 80 and over
Female
Follow-Up Studies
Humans
Hypercapnia diagnostic imaging
Image Processing, Computer-Assisted
Leukoencephalopathies diagnostic imaging
Magnetic Resonance Imaging
Male
Middle Aged
Neuropsychological Tests
Oxygen blood
Partial Pressure
Brain Mapping
Cerebrovascular Circulation physiology
Hypercapnia physiopathology
Leukoencephalopathies pathology
Leukoencephalopathies physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 2213-1582
- Volume :
- 11
- Database :
- MEDLINE
- Journal :
- NeuroImage. Clinical
- Publication Type :
- Academic Journal
- Accession number :
- 27358765
- Full Text :
- https://doi.org/10.1016/j.nicl.2016.05.008