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Comprehensive meta-analytical summary on human papillomavirus association with head and neck cancer.
- Source :
-
Experimental oncology [Exp Oncol] 2016 Jun; Vol. 38 (2), pp. 68-72. - Publication Year :
- 2016
-
Abstract
- An etiological role of high risk human papillomavirus (HPV) in the development of cervical cancer has been well established. Hence, attention of researchers has been focused on the role of HPV in pathogenesis of other malignancies, such as head and neck cancers. An analysis of epidemiological data on the prevalence of HPV infection among healthy people and patients with precancerous lesions and/or cancer is an important step in understanding the role of HPV in head and neck carcinogenesis. More and more data de-monstrate the impact of HPV infection on disease outcome. HPV-positive patients have been shown to have better responses to radiotherapy and better overall and disease-free survival than HPV-negative patients. This review presents data of the meta-analysis based on a large number of original studies on HPV prevalence in patients with precancerous lesions and in patients with oral, oropharyngeal and laryngeal cancers as well as findings on the impact of HPV infection on survival of these patients.
- Subjects :
- Head and Neck Neoplasms epidemiology
Humans
Laryngeal Neoplasms epidemiology
Mouth Neoplasms epidemiology
Oropharyngeal Neoplasms epidemiology
Papillomavirus Infections virology
Prevalence
Survival Analysis
Head and Neck Neoplasms virology
Laryngeal Neoplasms virology
Mouth Neoplasms virology
Oropharyngeal Neoplasms virology
Papillomaviridae isolation & purification
Papillomavirus Infections complications
Subjects
Details
- Language :
- English
- ISSN :
- 2312-8852
- Volume :
- 38
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Experimental oncology
- Publication Type :
- Academic Journal
- Accession number :
- 27356572