Supramolecular Self-Assembly of Histidine-Capped-Dialkoxy-Anthracene: A Visible-Light-Triggered Platform for Facile siRNA Delivery.

Authors :: Patil SP
Moosa BA
Alsaiari S
Alamoudi K
Alshamsan A
AlMalik A
Adil K
Eddaoudi M
Khashab NM
Source :: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2016 Sep 19; Vol. 22 (39), pp. 13789-13793. Date of Electronic Publication: 2016 Jul 28.
Publication Year :: 2016
Abstract: Supramolecular self-assembly of histidine-capped-dialkoxy-anthracene (HDA) results in the formation of light-responsive nanostructures. Single-crystal X-ray diffraction analysis of HDA shows two types of hydrogen bonding. The first hydrogen bond is established between the imidazole moieties while the second involves the oxygen atom of one amide group and the hydrogen atom of a second amide group. When protonated in acidic aqueous media, HDA successfully complexes siRNA yielding spherical nanostructures. This biocompatible platform controllably delivers siRNA with high efficacy upon visible-light irradiation leading up to 90 % of gene silencing in live cells.<br /> (© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Crystallography, X-Ray
HeLa Cells
Humans
Hydrogen Bonding
Light
Models, Molecular
Proto-Oncogene Proteins c-bcl-2 genetics
RNA, Small Interfering genetics
Anthracenes chemistry
Gene Transfer Techniques
Histidine analogs & derivatives
RNA Interference
RNA, Small Interfering administration & dosage

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