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Validation of an electronic program for pathologist training in the interpretation of a complex companion diagnostic immunohistochemical assay.
- Source :
-
Human pathology [Hum Pathol] 2016 Oct; Vol. 56, pp. 194-203. Date of Electronic Publication: 2016 Jun 24. - Publication Year :
- 2016
-
Abstract
- Companion diagnostics assay interpretation can select patients with the greatest targeted therapy benefits. We present the results from a prospective study demonstrating that pathologists can effectively learn immunohistochemical assay-interpretation skills from digital image-based electronic training (e-training). In this study, e-training was used to train board-certified pathologists to evaluate non-small cell lung carcinoma for eligibility for treatment with onartuzumab, a MET-inhibiting agent. The training program mimicked the live training that was previously validated in clinical trials for onartuzumab. A digital interface was developed for pathologists to review high-resolution, static images of stained slides. Sixty-four pathologists practicing in the United States enrolled while blinded to the type of training. After training, both groups completed a mandatory final test using glass slides. The results indicated both training modalities to be effective. Overall, 80.6% of e-trainees and 72.7% of live trainees achieved passing scores (at least 85%) on the final test. All study participants reported that their training experience was "good" and that they had received sufficient information to determine the adequacy of case slide staining to score each case. This study established that an e-training program conducted under highly controlled conditions can provide pathologists with the skills necessary to interpret a complex assay and that these skills can be equivalent to those achieved with face-to-face training using conventional microscopy. Programs of this type are scalable for global distribution and offer pathologists the potential for readily accessible and robust training in new companion diagnostic assays linked to novel, targeted, adjuvant therapies for cancer patients.<br /> (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Subjects :
- Antibodies, Monoclonal therapeutic use
Antineoplastic Agents therapeutic use
Biomarkers, Tumor antagonists & inhibitors
Carcinoma, Non-Small-Cell Lung drug therapy
Carcinoma, Non-Small-Cell Lung pathology
Clinical Competence
Clinical Decision-Making
Computer Graphics
Curriculum
Humans
Lung Neoplasms drug therapy
Lung Neoplasms pathology
Patient Selection
Predictive Value of Tests
Program Evaluation
Prospective Studies
Protein Kinase Inhibitors therapeutic use
Proto-Oncogene Proteins c-met antagonists & inhibitors
Reproducibility of Results
United States
Workflow
Biomarkers, Tumor analysis
Carcinoma, Non-Small-Cell Lung enzymology
Computer-Assisted Instruction
Education, Medical, Continuing methods
Immunohistochemistry
Inservice Training methods
Lung Neoplasms enzymology
Microscopy
Pathology, Clinical education
Proto-Oncogene Proteins c-met analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1532-8392
- Volume :
- 56
- Database :
- MEDLINE
- Journal :
- Human pathology
- Publication Type :
- Academic Journal
- Accession number :
- 27349303
- Full Text :
- https://doi.org/10.1016/j.humpath.2016.06.013