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Acquired Reactive Perforating Dermatosis is a Variant of Prurigo Nodularis.
- Source :
-
Acta dermato-venereologica [Acta Derm Venereol] 2017 Feb 08; Vol. 97 (2), pp. 249-254. - Publication Year :
- 2017
-
Abstract
- Patients with chronic pruritus may develop scratch-induced lesions with elevated borders and central necrosis. This so-called umbilicated type of prurigo (UP) is rare and is assumed to develop preferentially in the context of metabolic diseases. The aim of this study was to characterize UP in its clinical and histological dimension. Demographic and clinical data were collected from 23 patients with UP. Intensive light microscopical analysis of biopsied lesions was performed. Statistical comparison with previous results for prurigo nodularis (PN) showed that UP is clearly a subtype of PN. In addition, clinical and microscopic features of epidermal perforation identical to those in acquired reactive perforating dermatosis (ARDP) were observed. Hence, we suggest that ARDP is identical to UP and is therefore a subtype of PN. We assume that reduced wound healing capacities due to underlying systemic disorders, particularly diabetes mellitus and uraemia, underlie the pathomechanism of development of umbilicated skin lesions with a perforating aspect.
- Subjects :
- Adult
Aged
Aged, 80 and over
Chronic Disease
Diabetes Complications complications
Female
Fibrosis
Humans
Male
Middle Aged
Necrosis
Renal Insufficiency, Chronic complications
Retrospective Studies
Severity of Illness Index
Dermis pathology
Epidermis pathology
Prurigo etiology
Prurigo pathology
Pruritus complications
Subjects
Details
- Language :
- English
- ISSN :
- 1651-2057
- Volume :
- 97
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Acta dermato-venereologica
- Publication Type :
- Academic Journal
- Accession number :
- 27349279
- Full Text :
- https://doi.org/10.2340/00015555-2492