AFAP-1L1-mediated actin filaments crosslinks hinder Trypanosoma cruzi cell invasion and intracellular multiplication.

Authors :: de Araújo KCL
Teixeira TL
Machado FC
da Silva AA
Quintal APN
da Silva CV
Source :: Acta tropica [Acta Trop] 2016 Oct; Vol. 162, pp. 167-170. Date of Electronic Publication: 2016 Jun 24.
Publication Year :: 2016
Abstract: Host actin cytoskeleton polymerization has been shown to play an important role during Trypanosoma cruzi internalization into mammalian cell. The structure and dynamics of the actin cytoskeleton in cells are regulated by a vast number of actin-binding proteins. Here we aimed to verify the impact of AFAP-1L1, during invasion and multiplication of T. cruzi. Knocking-down AFAP-1L1 increased parasite cell invasion and intracellular multiplication. Thus, we have shown that the integrity of the machinery formed by AFAP-1L1 in actin cytoskeleton polymerization is important to hinder parasite infection.<br /> (Copyright © 2016 Elsevier B.V. All rights reserved.)

Subjects :: Animals
Chagas Disease parasitology
Cytoplasm metabolism
Female
Humans
Male
Mice
Mice, Inbred C57BL
Microfilament Proteins metabolism
Trypanosoma cruzi metabolism
Actin Cytoskeleton metabolism
Adaptor Proteins, Signal Transducing pharmacology
Microfilament Proteins pharmacology
Trypanosoma cruzi drug effects

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