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[A Preliminary Exploration on the Pathogenesis of Osteopenia in Patients with Hemophilia].
- Source :
-
Zhongguo shi yan xue ye xue za zhi [Zhongguo Shi Yan Xue Ye Xue Za Zhi] 2016 Jun; Vol. 24 (3), pp. 810-4. - Publication Year :
- 2016
-
Abstract
- Objective: To investigate the influencing factors and pathogenesis of osteopenia in the patients with hemophilia.<br />Methods: Twenty-three patients with hemophilia were admitted in the hospital affiliated to North China University of Science and technology from March to August 2015, including 13 severe cases, 10 mild and moderate cases. All the patients accepted the detection of serum I collagen cross-linking N terminal peptide (NTX I), osteoprotegerin (OPG), bone alkaline phosphatase (BALP), basic fibroblast growth factor (bFGF), insulin-like growth factor (IGF) and transforming growth factor-β1 (TGF-β1), the score scale of activity ability was recorded according to the criteria published by the U.S. Center for disease prevention and control in 2002, and 21 patients received the measurement of bone mineral density. According to the World Health Organization (WHO) definition, the clinical significance of bone mineral density (BMD) was assessed by measuring the Z level.<br />Results: Z level>-2 was recorded in 10 cases, Z≤-2 was recorded in 11 cases; the levels of body mass index (BMI) and human bone alkaline phosphatase (BALP) reflecting bone formation in 11 cases (Z≤-2) were lower than there in 10 cases (Z>-2) (P<0.05); the levels of BALP (r=0.489, P<0.05), IGF (r=0.538, P<0.05) and BMI (r=0.572, P<0.01) positively correlated significantly with BMD (P<0.05); the levels of bFGF (r=0.570, P<0.01) and OPG (r=0.505, P<0.05) positively correlated with NTX I, indicating bone destruction (P<0.05); the score of activity ability of severe patients was significantly lower than that of mild and moderate cases (P<0.05), BMD levels of these 2 groups were not statistically different (P>0.05).<br />Conclusion: The BMD level does not correlate with the clinial grouping of hemophilia, the low body mass index may be a risk factor for bone lose; the mechanism of hemophilia patient's bone lose may be related with the decrease of osteogenic activity, the IGF can prevent bone lose in hemophilia, the bFGF and OPG can promote bone metabolism of the patients with hemophilia.
- Subjects :
- Alkaline Phosphatase metabolism
Bone Density
Bone and Bones pathology
Collagen Type I metabolism
Fibroblast Growth Factor 2 metabolism
Humans
Osteogenesis
Osteoprotegerin metabolism
Peptides metabolism
Somatomedins metabolism
Transforming Growth Factor beta1 metabolism
Biomarkers
Bone Diseases, Metabolic pathology
Hemophilia A pathology
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1009-2137
- Volume :
- 24
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Zhongguo shi yan xue ye xue za zhi
- Publication Type :
- Academic Journal
- Accession number :
- 27342515
- Full Text :
- https://doi.org/10.7534/j.issn.1009-2137.2016.03.033