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Maximal mid-expiratory flow is a surrogate marker of lung clearance index for assessment of adults with bronchiectasis.
- Source :
-
Scientific reports [Sci Rep] 2016 Jun 24; Vol. 6, pp. 28467. Date of Electronic Publication: 2016 Jun 24. - Publication Year :
- 2016
-
Abstract
- Little is known about the comparative diagnostic value of lung clearance index (LCI) and maximal mid-expiratory flow (MMEF) in bronchiectasis. We compared the diagnostic performance, correlation and concordance with clinical variables, and changes of LCI and MMEF% predicted during bronchiectasis exacerbations (BEs). Patients with stable bronchiectasis underwent history inquiry, chest high-resolution computed tomography (HRCT), multiple-breath nitrogen wash-out test, spirometry and sputum culture. Patients who experienced BEs underwent these measurements during onset of BEs and 1 week following antibiotics therapy. Sensitivity analyses were performed in mild, moderate and severe bronchiectasis. We recruited 110 bronchiectasis patients between March 2014 and September 2015. LCI demonstrated similar diagnostic value with MMEF% predicted in discriminating moderate-to-severe from mild bronchiectasis. LCI negatively correlated with MMEF% predicted. Both parameters had similar concordance in reflecting clinical characteristics of bronchiectasis and correlated significantly with forced expiratory flow in one second, age, HRCT score, Pseudomonas aeruginosa colonization, cystic bronchiectasis, ventilation heterogeneity and bilateral bronchiectasis. In exacerbation cohort (nā=ā22), changes in LCI and MMEF% predicted were equally minimal during BEs and following antibiotics therapy. In sensitivity analyses, both parameters had similar diagnostic value and correlation with clinical variables. MMEF% predicted is a surrogate of LCI for assessing bronchiectasis severity.
- Subjects :
- Adult
Bronchiectasis microbiology
Cross-Sectional Studies
Cystic Fibrosis metabolism
Cystic Fibrosis microbiology
Cystic Fibrosis physiopathology
Female
Humans
Lung metabolism
Lung microbiology
Male
Pseudomonas aeruginosa pathogenicity
Spirometry methods
Tomography, X-Ray Computed methods
Biomarkers metabolism
Bronchiectasis metabolism
Bronchiectasis physiopathology
Exhalation physiology
Forced Expiratory Volume physiology
Lung physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 6
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 27339787
- Full Text :
- https://doi.org/10.1038/srep28467