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Whole-genome analysis of influenza A(H1N1)pdm09 viruses isolated in Uganda from 2009 to 2011.
- Source :
-
Influenza and other respiratory viruses [Influenza Other Respir Viruses] 2016 Nov; Vol. 10 (6), pp. 486-492. Date of Electronic Publication: 2016 Jul 19. - Publication Year :
- 2016
-
Abstract
- We report a whole-genome analysis of 19 influenza A(H1N1)pdm09 isolates from four Ugandan hospitals between 2009 and 2011. The isolates differed from the vaccine strain A/California/07/2009 by three amino acid substitutions P100S, S220T, and I338V in the hemagglutinin and by two amino acid substitutions V106I and N248D in the neuraminidase proteins with consistent mutations in all gene segments distinguishing isolates from the 2009/2010 to 2010/2011 seasons. Phylogenetic analysis showed low genetic evolution, with genetic distances of 0%-1.3% and 0.1%-1.6% for HA and NA genes, respectively. The amino acid substitutions did not lead to antigenic differences from the reference strains.<br /> (© 2016 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.)
- Subjects :
- Amino Acid Substitution
Antigens, Viral
Evolution, Molecular
Hemagglutinin Glycoproteins, Influenza Virus chemistry
Hemagglutinin Glycoproteins, Influenza Virus genetics
Humans
Influenza A Virus, H1N1 Subtype isolation & purification
Influenza, Human epidemiology
Neuraminidase chemistry
Neuraminidase genetics
Phylogeny
RNA, Viral genetics
Seasons
Sequence Analysis, RNA
Uganda epidemiology
Genome, Viral
Influenza A Virus, H1N1 Subtype genetics
Influenza, Human virology
Subjects
Details
- Language :
- English
- ISSN :
- 1750-2659
- Volume :
- 10
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Influenza and other respiratory viruses
- Publication Type :
- Academic Journal
- Accession number :
- 27339410
- Full Text :
- https://doi.org/10.1111/irv.12401