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Effect of pretreatment with antifungal agents on clinical outcomes in fungal keratitis.
- Source :
-
Clinical & experimental ophthalmology [Clin Exp Ophthalmol] 2016 Dec; Vol. 44 (9), pp. 763-767. Date of Electronic Publication: 2016 Jul 11. - Publication Year :
- 2016
-
Abstract
- Background: To determine if pretreatment with antifungal agents is predictive of worse clinical outcome in a fungal keratitis clinical trial.<br />Design: Non-pre-specified subgroup analysis of a randomized controlled trial in a tertiary hospital.<br />Participants: Three hundred twenty-three fungal ulcer cases with an enrolment visual acuity of 20/40 to 20/400.<br />Methods: The Mycotic Ulcer Treatment Trial I was a randomized, double-masked trial to determine the optimal treatment for filamentous fungal keratitis at the Aravind Eye Care System, India. Enrolled cases were randomized to receive topical natamycin or voriconazole. Prior antifungal medication use, dose and duration were collected at enrolment. A subgroup analysis was performed to determine if patients using natamycin or azoles at presentation have worse clinical outcomes compared with those who were not pretreated.<br />Main Outcome Measures: Three-month visual acuity (primary), 3-month infiltrate or scar size, corneal perforation and/or transplant and re-epithelialization time.<br />Results: Of the 323 patients enrolled, 44% presented on an antifungal agent. Pretreated patients had larger mean baseline infiltrate size (P < 0.001) and epithelial defect size (P = 0.02). Multivariate regression analysis demonstrated that pretreatment was associated with significantly worse 3-month visual acuity (P = 0.006), larger 3-month scar size (P < 0.001) and increased odds of corneal perforation and/or transplant (P = 0.001).<br />Conclusions: Fungal keratitis that is smear-positive despite being pretreated with appropriate antifungal agents appears to be a risk factor for worse outcomes, likely a result of initial ulcer severity and treatment failure. These patients may benefit from more aggressive multimodal therapy at a tertiary centre.<br />Competing Interests: None<br /> (© 2016 Royal Australian and New Zealand College of Ophthalmologists.)
- Subjects :
- Corneal Ulcer microbiology
Corneal Ulcer physiopathology
Double-Blind Method
Eye Infections, Fungal microbiology
Eye Infections, Fungal physiopathology
Female
Humans
Male
Middle Aged
Tertiary Care Centers
Antibiotic Prophylaxis
Antifungal Agents therapeutic use
Corneal Ulcer prevention & control
Eye Infections, Fungal prevention & control
Natamycin therapeutic use
Vancomycin therapeutic use
Visual Acuity physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1442-9071
- Volume :
- 44
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Clinical & experimental ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 27329780
- Full Text :
- https://doi.org/10.1111/ceo.12794