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Risk of asthma in heterozygous carriers for cystic fibrosis: A meta-analysis.
- Source :
-
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society [J Cyst Fibros] 2016 Sep; Vol. 15 (5), pp. 563-7. Date of Electronic Publication: 2016 Jun 17. - Publication Year :
- 2016
-
Abstract
- Background: Patients with cystic fibrosis (CF) have a higher prevalence of asthma than the background population, however, it is unclear whether heterozygous CF carriers are susceptible to asthma. Given this, a meta-analysis is necessary to determine the veracity of the association of CF heterozygosity with asthma.<br />Methods: We screened the medical literature from 1966 to 2015 and performed a meta-analysis to determine the risk of asthma in CF heterozygotes vs. non-carriers.<br />Results: Aggregating data from 15 studies, the odds ratio for asthma in CF heterozygotes compared with non-carriers was significantly elevated at 1.61 (95% CI: 1.18-2.21). When analyzing the studies considered of high quality in which asthma was diagnosed by a physician, the patients were >18years, or study size was ≥500, the trend remained the same, that heterozygous carriers of CF had elevated risk for asthma.<br />Conclusions: The results show that heterozygous carriers for CF have a higher risk of asthma than non-carriers.<br /> (Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1873-5010
- Volume :
- 15
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
- Publication Type :
- Academic Journal
- Accession number :
- 27324553
- Full Text :
- https://doi.org/10.1016/j.jcf.2016.06.001