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Maternal Metabolic Syndrome Programs Mitochondrial Dysfunction via Germline Changes across Three Generations.
- Source :
-
Cell reports [Cell Rep] 2016 Jun 28; Vol. 16 (1), pp. 1-8. Date of Electronic Publication: 2016 Jun 16. - Publication Year :
- 2016
-
Abstract
- Maternal obesity impairs offspring health, but the responsible mechanisms are not fully established. To address this question, we fed female mice a high-fat/high-sugar diet from before conception until weaning and then followed the outcomes in the next three generations of offspring, all fed a control diet. We observed that female offspring born to obese mothers had impaired peripheral insulin signaling that was associated with mitochondrial dysfunction and altered mitochondrial dynamic and complex proteins in skeletal muscle. This mitochondrial phenotype persisted through the female germline and was passed down to the second and third generations. Our results indicate that maternal programming of metabolic disease can be passed through the female germline and that the transfer of aberrant oocyte mitochondria to subsequent generations may contribute to the increased risk for developing insulin resistance.<br /> (Copyright © 2016. Published by Elsevier Inc.)
- Subjects :
- Animals
Diet, High-Fat
Dietary Carbohydrates
Female
Glucose Intolerance complications
Inheritance Patterns
Insulin Resistance
Male
Metabolic Syndrome complications
Mice, Inbred C57BL
Mitochondria metabolism
Mitochondria ultrastructure
Mitochondrial Dynamics
Muscle, Skeletal metabolism
Muscle, Skeletal ultrastructure
Oocytes metabolism
Oocytes ultrastructure
Pregnancy
Signal Transduction
Germ Cells metabolism
Metabolic Syndrome metabolism
Mitochondria pathology
Subjects
Details
- Language :
- English
- ISSN :
- 2211-1247
- Volume :
- 16
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cell reports
- Publication Type :
- Academic Journal
- Accession number :
- 27320925
- Full Text :
- https://doi.org/10.1016/j.celrep.2016.05.065