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Integrating Networks and Proteomics: Moving Forward.
- Source :
-
Trends in biotechnology [Trends Biotechnol] 2016 Dec; Vol. 34 (12), pp. 951-959. Date of Electronic Publication: 2016 Jun 13. - Publication Year :
- 2016
-
Abstract
- Networks can resolve many analytical problems in proteomics, including incomplete coverage and inconsistency. Despite high expectations, network-related research in proteomics has experienced only modest growth. In practice, most current research examines non-quantitative usages, for example determining physical interactions among proteins or contextualizing a differential protein list, rather than addressing practical quantitative usages, for example predicting missing proteins or making sample-class predictions. Moreover, many applications are irreproducible and are not widely adopted owing to a lack of common standards, particularly evaluation criteria and gold-standard datasets. A concerted drive towards quantitative applications and convergence towards common standards is essential for 'network-based proteomics' to realize its development potential and make meaningful contributions to clinical applications.<br /> (Copyright © 2016 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-3096
- Volume :
- 34
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Trends in biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 27312055
- Full Text :
- https://doi.org/10.1016/j.tibtech.2016.05.015