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Conventional treatment regimens for ulcerative colitis alleviate fatigue - an observational cohort study.
- Source :
-
Scandinavian journal of gastroenterology [Scand J Gastroenterol] 2016 Oct; Vol. 51 (10), pp. 1213-9. Date of Electronic Publication: 2016 Jun 16. - Publication Year :
- 2016
-
Abstract
- Objective: The aim of the study was to investigate the course of fatigue in a conventional inflammatory bowel disease treatment setting.<br />Materials and Methods: Eighty-two patients with newly diagnosed ulcerative colitis were included in an observational cohort study and received conventional non-biological drug treatment for 3 months. Colonoscopy was performed at diagnosis and after 3 months, disease activity was assessed by Mayo score and measurements of serum C-reactive protein (CRP) and fecal calprotectin levels. Fatigue was evaluated using the fatigue visual analog scale (fVAS). Mood was assessed with the hospital anxiety and depression scale (HADS). Associations between fVAS scores and time; age; CRP, fecal calprotectin, hemoglobin, and ferritin levels; and Mayo scores, Mayo endoscopic scores, and HADS depression subscale (HADS-D) scores were explored.<br />Results: Median fVAS scores decreased, as did Mayo scores and CRP and fecal calprotectin concentrations. HADS-D scores remained unchanged, whereas hemoglobin levels increased after 3 months. Increased fVAS scores were associated with higher ferritin, Mayo and HADS-D scores. There were no associations between fVAS scores and CRP, fecal calprotectin, or Mayo endoscopic scores. Colonic disease distribution did not influence fatigue significantly.<br />Conclusions: Disease activity and fatigue improved after 3 months of conventional ulcerative colitis treatment. Over time, more severe fatigue was associated with more ulcerative colitis symptoms, but not with objective disease activity markers or colonic disease distribution. A clinical setting of standard treatment regimens and medical attention may alleviate fatigue in IBD patients.
- Subjects :
- Adolescent
Adrenal Cortex Hormones therapeutic use
Adult
Aged
Biomarkers analysis
C-Reactive Protein analysis
Cohort Studies
Colonoscopy
Feces chemistry
Female
Hemoglobins analysis
Humans
Leukocyte L1 Antigen Complex analysis
Male
Mesalamine administration & dosage
Middle Aged
Norway
Regression Analysis
Severity of Illness Index
Young Adult
Colitis, Ulcerative complications
Colitis, Ulcerative drug therapy
Fatigue epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1502-7708
- Volume :
- 51
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Scandinavian journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 27310658
- Full Text :
- https://doi.org/10.1080/00365521.2016.1195869