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Liver Stiffness Evaluation by Transient Elastography in Type 2 Diabetes Mellitus Patients with Ultrasound-proven Steatosis.
- Source :
-
Journal of gastrointestinal and liver diseases : JGLD [J Gastrointestin Liver Dis] 2016 Jun; Vol. 25 (2), pp. 167-74. - Publication Year :
- 2016
-
Abstract
- Background and Aims: Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. The aim of our study was to evaluate a population of diabetic patients regarding the severity of liver steatosis and liver fibrosis.<br />Methods: The study included 392 type 2 diabetic patients prospectively randomized, evaluated in the same session by transabdominal ultrasound to assess steatosis and by liver elastography to assess fibrosis (Transient Elastography - TE, FibroScan, EchoSens). Steatosis severity was graded using a semi-quantitative scale (S0-no steatosis; S1-mild steatosis; S2-moderate steatosis; S3-severe steatosis). For differentiation between stages of liver fibrosis, the following cut-off values were used (Wong et al., 2010): F2-F3: 7-10.2kPa, F4>/=10.3 kPa.<br />Results: Reliable elastographic measurements were obtained in 76% (298/392) patients. By using the proposed cut-off values, significant fibrosis (F2-F3) was found in 18.8% (56) patients with steatosis, while 13.8% (41) had cirrhosis (F4). Significant fibrosis (F2-F3) was found in 20.4% (20/98) of the patients with S1, in 18.6% (22/118) of those with S2 and in 31.8% (14/44) of those with S3, while cirrhosis (F4) was diagnosed in 7.1% (7/98) patients with S1, in 20.3% (24/118) of those with S2 and in 22.7% (10/44) of those with S3.<br />Conclusions: Liver steatosis diagnosed by ultrasound is very frequently found in type 2 diabetes mellitus patients, more than half of them having moderate/severe steatosis. A significant liver stiffness increase was found in more than 30% of these patients. Liver stiffness assessment in type 2 diabetic patients should be performed systematically to identify those with significant liver fibrosis.
- Subjects :
- Aged
Diabetes Mellitus, Type 2 diagnosis
Female
Humans
Liver Cirrhosis complications
Male
Middle Aged
Non-alcoholic Fatty Liver Disease complications
Predictive Value of Tests
Prospective Studies
Reproducibility of Results
Romania
Severity of Illness Index
Diabetes Mellitus, Type 2 complications
Elasticity Imaging Techniques
Liver diagnostic imaging
Liver Cirrhosis diagnostic imaging
Non-alcoholic Fatty Liver Disease diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1842-1121
- Volume :
- 25
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of gastrointestinal and liver diseases : JGLD
- Publication Type :
- Academic Journal
- Accession number :
- 27308647
- Full Text :
- https://doi.org/10.15403/jgld.2014.1121.252.lsf