Different cell fates after mitotic slippage: From aneuploidy to polyploidy.

Authors :: Ohashi A
Source :: Molecular & cellular oncology [Mol Cell Oncol] 2015 Oct 06; Vol. 3 (2), pp. e1088503. Date of Electronic Publication: 2015 Oct 06 (Print Publication: 2016).
Publication Year :: 2015
Abstract: The molecular mechanism responsible for cell fate after mitotic slippage remains unclear. We investigated the different postmitotic effects of aneuploidy versus polyploidy using chemical inhibitors of centromere-associated protein-E (CENP-E) and kinesin family member 11 (KIF11, also known as Eg5). Aneuploidy caused substantial proteotoxic stress and DNA damage accompanied by p53-mediated postmitotic apoptosis, whereas polyploidy did not induce these antiproliferative effects.