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Training at non-damaging intensities facilitates recovery from muscle atrophy.
- Source :
-
Muscle & nerve [Muscle Nerve] 2017 Feb; Vol. 55 (2), pp. 243-253. Date of Electronic Publication: 2016 Nov 07. - Publication Year :
- 2017
-
Abstract
- Introduction: Resistance training promotes recovery from muscle atrophy, but optimum training programs have not been established. We aimed to determine the optimum training intensity for muscle atrophy.<br />Methods: Mice recovering from atrophied muscles after 2 weeks of tail suspension underwent repeated isometric training with varying joint torques 50 times per day.<br />Results: Muscle recovery assessed by maximal isometric contraction and myofiber cross-sectional areas (CSAs) were facilitated at 40% and 60% maximum contraction strength (MC), but at not at 10% and 90% MC. At 60% and 90% MC, damaged and contained smaller diameter fibers were observed. Activation of myogenic satellite cells and a marked increase in myonuclei were observed at 40%, 60%, and 90% MC.<br />Conclusions: The increases in myofiber CSAs were likely caused by increased myonuclei formed through fusion of resistance-induced myofibers with myogenic satellite cells. These data indicate that resistance training without muscle damage facilitates efficient recovery from atrophy. Muscle Nerve 55: 243-253, 2017.<br /> (© 2016 Wiley Periodicals, Inc.)
- Subjects :
- Analysis of Variance
Electric Stimulation
Female
Hindlimb Suspension
Histocompatibility Antigens Class I metabolism
Humans
Isometric Contraction
Male
Muscular Atrophy physiopathology
MyoD Protein metabolism
Myogenin metabolism
PAX7 Transcription Factor metabolism
Muscle, Skeletal physiology
Muscular Atrophy rehabilitation
Recovery of Function physiology
Resistance Training methods
Subjects
Details
- Language :
- English
- ISSN :
- 1097-4598
- Volume :
- 55
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Muscle & nerve
- Publication Type :
- Academic Journal
- Accession number :
- 27301985
- Full Text :
- https://doi.org/10.1002/mus.25218