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Human whole blood 1 H 2 O transverse relaxation with gadolinium-based contrast reagents: Magnetic susceptibility and transmembrane water exchange.
- Source :
-
Magnetic resonance in medicine [Magn Reson Med] 2017 May; Vol. 77 (5), pp. 2015-2027. Date of Electronic Publication: 2016 Jun 14. - Publication Year :
- 2017
-
Abstract
- Purpose: To characterize transverse relaxation in oxygenated whole blood with extracellular gadolinium-based contrast reagents by experiment and simulation.<br />Methods: Experimental measurements of transverse <superscript>1</superscript> H <subscript>2</subscript> O relaxation from oxygenated whole human blood and plasma were made at 1.5 and 3.0 Tesla. Spin-echo refocused and free-induction decays are reported for blood and plasma samples containing four different contrast reagents (gadobenate, gadoteridol, gadofosveset, and gadobutrol), each present at concentrations ranging from 1 to 18 mM (i.e., mmol (contrast reagent (CR))/L (blood)). Monte Carlo simulations were conducted to ascertain the molecular mechanisms underlying relaxation. These consisted of random walks of water molecules in a large ensemble of randomly oriented erythrocytes. Bulk magnetic susceptibility (BMS) differences between the extra- and intracellular compartments were taken into account. All key parameters for these simulations were taken from independent published measurements: they include no adjustable variables.<br />Results: Transverse relaxation is much more rapid in whole blood than in plasma, and the large majority of this dephasing is reversible by spin echo. Agreement between the experimental data and simulated results is remarkably good.<br />Conclusion: Extracellular field inhomogeneities alone make very small contributions, whereas the orientation-dependent BMS intracellular resonance frequencies lead to the majority of transverse dephasing. Equilibrium exchange of water molecules between the intra- and extracellular compartments plays a significant role in transverse dephasing. Magn Reson Med 77:2015-2027, 2017. © 2016 International Society for Magnetic Resonance in Medicine.<br /> (© 2016 International Society for Magnetic Resonance in Medicine.)
- Subjects :
- Computer Simulation
Heterocyclic Compounds chemistry
Humans
Hydrogen-Ion Concentration
Magnetics
Meglumine analogs & derivatives
Meglumine chemistry
Monte Carlo Method
Organometallic Compounds chemistry
Plasma chemistry
Blood Chemical Analysis
Contrast Media chemistry
Gadolinium chemistry
Oxygen chemistry
Water chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1522-2594
- Volume :
- 77
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Magnetic resonance in medicine
- Publication Type :
- Academic Journal
- Accession number :
- 27297589
- Full Text :
- https://doi.org/10.1002/mrm.26284