Back to Search
Start Over
Release of selected amino acids from zinc carriers.
- Source :
-
Acta pharmaceutica (Zagreb, Croatia) [Acta Pharm] 2016 Jun 01; Vol. 66 (2), pp. 269-77. - Publication Year :
- 2016
-
Abstract
- The paper deals with the results of an investigation of the release of selected amino acids (histidine, tryptophan, tyrosine) from model suspensions prepared by co-precipitation with zinc chloride. It has been proven that the influence of the Zn(II)/amino acid molar ratio on dissolution profiles of the tested amino acids and dissolution half-life (t1/2) of histidine or tryptophan is significant. The amount of amino acid in the dispersed phase (supporting dose) is a determinant of the amino acid release profile. There is a minimal supporting dose (30.0 μmol of histidine or 17.4 μmol of tryptophan) that provides release of similar amounts of amino acid (4.1-4.6 μmol of histidine or 8.7-9.9 μmol of tryptophan) after the same time intervals. The tyrosine release profiles follow first order kinetics since the supporting dose (0.9-11.2 μmol) is limited by the tyrosine low solubility in water.
Details
- Language :
- English
- ISSN :
- 1846-9558
- Volume :
- 66
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Acta pharmaceutica (Zagreb, Croatia)
- Publication Type :
- Academic Journal
- Accession number :
- 27279069
- Full Text :
- https://doi.org/10.1515/acph-2016-0024