A Novel Peptide Hydrogel for an Antimicrobial Bandage Contact Lens.

Authors :: Gallagher AG
Alorabi JA
Wellings DA
Lace R
Horsburgh MJ
Williams RL
Source :: Advanced healthcare materials [Adv Healthc Mater] 2016 Aug; Vol. 5 (16), pp. 2013-8. Date of Electronic Publication: 2016 Jun 08.
Publication Year :: 2016
Abstract: A peptide hydrogel with an antimicrobial activity is developed as a bandage contact lens. The antimicrobial activity is enhanced with the addition of the biomolecules penicillin G or poly-ε-lysine and is positive against Staphylococcus aureus and Escherichia coli. The lens is also noncytotoxic toward a human corneal epithelial cell line and as a consequence is of great potential as a drug-eluting bandage lens replacing conventional corneal ulcer treatment.<br /> (© 2016 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)