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HIV infection and bone disease.
- Source :
-
Journal of internal medicine [J Intern Med] 2016 Oct; Vol. 280 (4), pp. 350-8. Date of Electronic Publication: 2016 Jun 06. - Publication Year :
- 2016
-
Abstract
- The success of antiretroviral therapy in treating HIV infection has greatly prolonged life expectancy in affected individuals, transforming the disease into a chronic condition. A number of HIV-associated non-AIDS comorbidities have emerged in the ageing HIV-infected population, including osteoporosis and increased risk of fracture. The pathogenesis of fracture is multifactorial with contributions from both traditional and HIV-specific risk factors. Significant bone loss occurs on initiation of antiretroviral therapy but stabilizes on long-term therapy. Fracture risk assessment should be performed in HIV-infected individuals and bone mineral density measured when indicated. Lifestyle measures to optimize bone health should be advised and, in individuals at high risk of fracture, treatment with bisphosphonates considered.<br /> (© 2016 The Association for the Publication of the Journal of Internal Medicine.)
Details
- Language :
- English
- ISSN :
- 1365-2796
- Volume :
- 280
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of internal medicine
- Publication Type :
- Academic Journal
- Accession number :
- 27272530
- Full Text :
- https://doi.org/10.1111/joim.12520