Back to Search
Start Over
Acidic fibroblast growth factor enhances peripheral nerve regeneration in vivo.
- Source :
-
Plastic and reconstructive surgery [Plast Reconstr Surg] 1989 Jun; Vol. 83 (6), pp. 1013-9; discussion 1020-1. - Publication Year :
- 1989
-
Abstract
- When added to a collagen-filled nerve guide, purified acidic fibroblast growth factor (aFGF) increased the number of myelinated axons that regenerated across a 5-mm nerve gap distance. In addition, a greater number of primary sensory and motor neurons extended axons through the nerve guide in animals treated with aFGF. Thus the effect of aFGF on peripheral nerve regeneration is not simply an increase in axonal branching within the nerve guide tube. This is the first highly purified growth factor since nerve growth factor that has been shown to promote nerve regeneration in vivo. This experimental model provides a convenient and quantitative means to assess the effects of putative neuronotropic factors on peripheral nerve regeneration in vivo.
- Subjects :
- Action Potentials drug effects
Animals
Collagen pharmacology
Electrophysiology
Heparin pharmacology
Male
Nerve Fibers, Myelinated drug effects
Rats
Rats, Inbred Strains
Sciatic Nerve drug effects
Fibroblast Growth Factors pharmacology
Nerve Regeneration drug effects
Peripheral Nerves drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0032-1052
- Volume :
- 83
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Plastic and reconstructive surgery
- Publication Type :
- Academic Journal
- Accession number :
- 2727148