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Prolonged respiratory disorder predicts adverse prognosis in infants with end-stage kidney disease.
- Source :
-
Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2016 Nov; Vol. 31 (11), pp. 2127-36. Date of Electronic Publication: 2016 Jun 07. - Publication Year :
- 2016
-
Abstract
- Background: Among comorbidities, pulmonary hypoplasia (PH) is known as a significant risk factor for mortality in infants with end-stage kidney disease (ESKD). However, the final outcomes of infants with both ESKD and PH are still not well defined, as the diagnosis modality, and definition of PH severity remain ambiguous.<br />Methods: Children initiating peritoneal dialysis during infancy from 1990 to 2015 were followed until death, date of last contact, or the end of 2015. We examined the long-term outcome of children with congenital pulmonary disorders by studying infants with prolonged respiratory disorders of greater than 28 days duration after birth and evaluated risk factors for mortality.<br />Results: Forty-six children were followed (median follow-up, 9.23 years), and classified as children without (nā=ā38; Group A) or with (nā=ā8; Group B) a prolonged respiratory disorder. Overall actuarial 5 year survival rate in this cohort was 79.5 %. The survival curve in Group B showed a significant decline compared with Group A. Prolonged respiratory disorder was significantly associated with mortality by multivariate analysis (hazard ratio, 8.32).<br />Conclusions: Infants who initiate peritoneal dialysis complicated by prolonged respiratory disorders have increased adverse risk factors for mortality; therefore, withholding aggressive treatment should be considered.
- Subjects :
- Comorbidity
Female
Follow-Up Studies
Humans
Infant
Kaplan-Meier Estimate
Prognosis
Proportional Hazards Models
Retrospective Studies
Risk Factors
Survival Rate
Time Factors
Treatment Outcome
Abnormalities, Multiple epidemiology
Kidney Failure, Chronic epidemiology
Kidney Failure, Chronic therapy
Lung abnormalities
Lung Diseases epidemiology
Peritoneal Dialysis adverse effects
Urogenital Abnormalities epidemiology
Vesico-Ureteral Reflux epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1432-198X
- Volume :
- 31
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Pediatric nephrology (Berlin, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 27271033
- Full Text :
- https://doi.org/10.1007/s00467-016-3430-5