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Hypo- and Hyper-Assembly Diseases of RNA-Protein Complexes.

Authors :
Shukla S
Parker R
Source :
Trends in molecular medicine [Trends Mol Med] 2016 Jul; Vol. 22 (7), pp. 615-628. Date of Electronic Publication: 2016 Jun 03.
Publication Year :
2016

Abstract

A key aspect of cellular function is the proper assembly and utilization of ribonucleoproteins (RNPs). Recent studies have shown that hyper- or hypo-assembly of various RNPs can lead to human diseases. Defects in the formation of RNPs lead to 'RNP hypo-assembly diseases', which can be caused by RNA degradation outcompeting RNP assembly. By contrast, excess RNP assembly, either in higher order RNP granules, or due to the expression of repeat-containing RNAs, can lead to 'RNP hyper-assembly diseases'. Here, we discuss the most recent advances in understanding the cause of disease onset, as well as potential therapies from the aspect of modulating RNP assembly in the cell, which presents a novel route to the treatment of these diseases.<br /> (Copyright © 2016 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1471-499X
Volume :
22
Issue :
7
Database :
MEDLINE
Journal :
Trends in molecular medicine
Publication Type :
Academic Journal
Accession number :
27263464
Full Text :
https://doi.org/10.1016/j.molmed.2016.05.005