YAP/TAZ as therapeutic targets in cancer.

Authors :: Zanconato F
Battilana G
Cordenonsi M
Piccolo S
Source :: Current opinion in pharmacology [Curr Opin Pharmacol] 2016 Aug; Vol. 29, pp. 26-33. Date of Electronic Publication: 2016 Jun 02.
Publication Year :: 2016
Abstract: The biology and regulation of YAP and TAZ, two closely related transcriptional regulators, are receiving increasing attention owing to their fundamental roles in organ growth, tissue repair and cancer. In particular, the widespread activation of YAP/TAZ in carcinomas, and the crucial role of YAP/TAZ activation for many 'hallmarks' of cancer are indicating YAP/TAZ as prime targets for designing anti-cancer drugs. Here, we start from the known modalities to regulate YAP/TAZ to highlight possible routes of therapeutic intervention.<br /> (Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.)