Synthesis and evaluation of biphenyl derivatives as potential downregulators of VEGF protein secretion and telomerase-related gene expressions.

Authors :: Sánchez-Peris M
Falomir E
Murga J
Carda M
Marco JA
Source :: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2016 Jul 15; Vol. 24 (14), pp. 3108-15. Date of Electronic Publication: 2016 May 18.
Publication Year :: 2016
Abstract: A group of 47 biphenyl functionalized compounds, prepared by means of Suzuki couplings, has been investigated for their cytotoxicity on two tumoral cell lines (HT-29 and MCF-7) and one non tumoral cell line (HEK-293). 29 selected compounds have been investigated for their ability to inhibit the production of the vascular endothelial growth factor (VEGF). Subsequently, the capacity of the compounds to downregulate the expression of the VEGF, h-TERT and c-Myc genes, the two latter involved in the control of the activation of telomerase, has also been determined.<br /> (Copyright © 2016 Elsevier Ltd. All rights reserved.)

Subjects :: Biphenyl Compounds chemistry
Genes, myc
HEK293 Cells
HT29 Cells
Humans
MCF-7 Cells
Structure-Activity Relationship
Vascular Endothelial Growth Factor A genetics
Biphenyl Compounds chemical synthesis
Biphenyl Compounds pharmacology
Down-Regulation drug effects
Telomerase genetics
Vascular Endothelial Growth Factor A metabolism

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