Back to Search
Start Over
A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins.
- Source :
-
Nature communications [Nat Commun] 2016 Jun 03; Vol. 7, pp. 11685. Date of Electronic Publication: 2016 Jun 03. - Publication Year :
- 2016
-
Abstract
- Phytophthora pathogens secrete an array of specific effector proteins to manipulate host innate immunity to promote pathogen colonization. However, little is known about the host targets of effectors and the specific mechanisms by which effectors increase susceptibility. Here we report that the soybean pathogen Phytophthora sojae uses an essential effector PsAvh262 to stabilize endoplasmic reticulum (ER)-luminal binding immunoglobulin proteins (BiPs), which act as negative regulators of plant resistance to Phytophthora. By stabilizing BiPs, PsAvh262 suppresses ER stress-triggered cell death and facilitates Phytophthora infection. The direct targeting of ER stress regulators may represent a common mechanism of host manipulation by microbes.
- Subjects :
- Immunoglobulins metabolism
Glycine max immunology
Glycine max metabolism
Carrier Proteins metabolism
Cell Death immunology
Endoplasmic Reticulum Stress immunology
Immunoglobulins immunology
Phytophthora metabolism
Plant Diseases immunology
Plant Immunity immunology
Plant Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 7
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 27256489
- Full Text :
- https://doi.org/10.1038/ncomms11685