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Urine and serum biomonitoring of exposure to environmental estrogens II: Soy isoflavones and zearalenone in pregnant women.
- Source :
-
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2016 Sep; Vol. 95, pp. 19-27. Date of Electronic Publication: 2016 May 30. - Publication Year :
- 2016
-
Abstract
- Unlabelled: Urine and serum biomonitoring was used to measure internal exposure to selected dietary estrogens in a cohort of 30 pregnant women. Exposure was measured over a period comprising one-half day in the field (6 h) and one day in a clinic (24 h). Biomonitoring of the dietary phytoestrogens genistein (GEN), daidzein (DDZ) and equol (EQ), as well as the mycoestrogen, zearalenone (ZEN) and its congeners, was conducted using UPLC-MS/MS. Biomonitoring revealed evidence of internal exposure to naturally occurring dietary estrogens during pregnancy. Urinary concentrations of total GEN, DDZ and EQ were similar to levels reported for general adult U.S.<br />Population: Measurable concentrations of total (parent and metabolites) GEN, DDZ and EQ were present in 240, 207 and 2 of 270 serum samples, respectively. Six out of 30 subjects had measurable concentrations of unconjugated GEN and/or DDZ in serum between 0.6 and 7.1 nM. Urine to serum total isoflavone ratios for GEN, DDZ and EQ were 13, 47, and 180, respectively. ZEN and its reductive metabolite, α-zearalenol (α-ZEL), were present in pregnant women (11 out of 30 subjects) as conjugates at levels near the limit of quantification. The average total urinary concentration was 0.10 μg/L for ZEN and 0.11 μg/L for α-ZEL.<br /> (Copyright © 2016. Published by Elsevier Ltd.)
- Subjects :
- Adult
Cohort Studies
Diet
Equol analysis
Female
Genistein analysis
Humans
Pregnancy
Tandem Mass Spectrometry methods
Environmental Exposure
Environmental Monitoring methods
Estrogens administration & dosage
Isoflavones analysis
Phytoestrogens blood
Phytoestrogens urine
Glycine max chemistry
Zearalenone analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6351
- Volume :
- 95
- Database :
- MEDLINE
- Journal :
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- Publication Type :
- Academic Journal
- Accession number :
- 27255803
- Full Text :
- https://doi.org/10.1016/j.fct.2016.05.021