Back to Search
Start Over
Glutamine Synthetase Immunoreactivity in Peritumoral Hyperplasia in Liver:  Case Report of a Metastatic Paraganglioma With Focal Nodular Hyperplasia-Like Changes and Review of an Additional 54 Liver Masses.
- Source :
-
American journal of clinical pathology [Am J Clin Pathol] 2016 Aug; Vol. 146 (2), pp. 254-61. Date of Electronic Publication: 2016 May 31. - Publication Year :
- 2016
-
Abstract
- Objectives: Focal nodular hyperplasia (FNH) and peritumoral hyperplasia in the liver exhibit increased immunoreactivity for glutamine synthetase (GS). We observed FNH-like changes with map-like GS staining surrounding a metastatic paraganglioma and sought to determine how often such changes occur around primary and metastatic liver lesions.<br />Methods: We performed GS immunohistochemistry in liver cases of 20 metastatic neuroendocrine carcinomas (NECs), 21 metastatic colon carcinomas (CCs), seven hepatocellular carcinomas (HCCs), and six FNHs and assessed lesions for size, degree of fibrosis (scored 1-3), and peritumoral hyperplasia.<br />Results: Most NEC or CC cases had few peritumoral hyperplastic features. Three NECs, two CCs, and one HCC (13%) had patchy GS staining at the periphery of the lesions. One CC case had both histologic and immunohistochemical peritumoral hyperplasia.<br />Conclusions: Peritumoral hyperplasia or FNH-like changes are uncommon findings around primary or metastatic lesions in the liver. GS immunohistochemistry assists in distinguishing true peritumoral hyperplasia from mass effect.<br /> (© American Society for Clinical Pathology, 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- Adenocarcinoma diagnosis
Adenocarcinoma secondary
Adult
Carcinoma, Hepatocellular diagnosis
Carcinoma, Hepatocellular secondary
Colonic Neoplasms pathology
Diagnosis, Differential
Female
Glutamate-Ammonia Ligase analysis
Humans
Immunohistochemistry
Liver Neoplasms enzymology
Paraganglioma, Extra-Adrenal secondary
Biomarkers, Tumor analysis
Focal Nodular Hyperplasia diagnosis
Glutamate-Ammonia Ligase biosynthesis
Liver Neoplasms diagnosis
Liver Neoplasms secondary
Paraganglioma, Extra-Adrenal diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1943-7722
- Volume :
- 146
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- American journal of clinical pathology
- Publication Type :
- Academic Journal
- Accession number :
- 27247379
- Full Text :
- https://doi.org/10.1093/ajcp/aqw056